Similar to normal B cells [86] the effects of BCR anergy on affected CLL cells can act globally to inhibit signaling by other receptors and are demonstrated in a recent report showing that anergic CLL cells fail to migrate toward CXCL12 because endosome recycling of Rap1 is impaired [87]. This evidence concerns the gene CXCL12 and B-cell chronic lymphocytic leukemia.