Finally, a recently published abstract has provided support for Lyn-mediated negative signaling in CLL pathogenesis and reported that disease development is inhibited in the Tcl-1 transgenic mouse model of CLL, a model that closely mimics UM-CLL in humans [107, 108], when Lyn is deleted [109]. The gene discussed is LYN; the disease is B-cell chronic lymphocytic leukemia.