Thus, considering that RhoH expression correlates with ZAP70 in CLL cells, a plausible mechanism is that it coordinates ZAP70 and Lck to the BCR to facilitate hyperphosphorylation of HS1 during BCR engagement and thereby release CLL cells from the effects of anergy and promote increased cell mobility. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.