SOD1 and fibrosis: EUK-8, as a SOD mimetic, improved LV end-systolic dimensions and fractional shortening, prevented myocardial oxidant stress, attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis in mice subjected to pressure overload [113]. In vitro, the SOD mimetics tempol and EUK-8 could also reduce collagen production in Ang-II-treated fibroblasts [73].