Furthermore, Ndisang and Jadhav reported that upregulating the heme oxygenase system suppressed LV hypertrophy in spontaneously hypertensive adult rats and was accompanied with attenuated extracellular matrix remodeling, whereas HO-1 was blocked with chromium mesoporphyrin-exacerbated cardiac fibrosis/hypertrophy [68]. The gene discussed is HMOX1; the disease is cardiac hypertrophy.