Moreover, recent evidence from our group has highlighted the functional significance of a cross-talk among ARF and ATM (Velimezi et al., 2013; Kotsinas et al., 2014) and how ARF can act as an “auxiliary” tumor suppressive mechanism throughout cancer progression in case the DDR pathway is compromised (Velimezi et al., 2013). Here, CDKN2A is linked to neoplasm.