CDKN2A and cancer: Apart from cancer (Sherr, 2006), accumulating data highlight ARF as a versatile protein implicated in various physiological processes including developmental ones (Thornton et al., 2005; Gromley et al., 2009; Churchman et al., 2011), immunomodulation (Través et al., 2012) and ribosomal ribonucleic acid (rRNA) maturation (Sugimoto et al., 2003), as well as pathological ones, such as atherogenesis (González-Navarro et al., 2010).