IGHE and neoplasm: The “inappropriate Th2 skewing” hypothesis (186) suggests that type 2 mediators – such as IL-4, IL-10, IL-13 – may redirect tissue immunity away from a potently anti-tumor and cytolytic Th1 response, toward an ineffective Th2 response, where IgE is produced and directed toward allergens and not tumor-specific or tumor-associated antigens.