The anti-tumor response could not be attributed to the luciferase expressed by the injected Luc-DC since first, luciferase has been shown to be poorly immunogenic (8, 9); second, Luc-DC induce tumors in large T and GFP-tolerant mice; and third, because CD8+ T cells isolated from tumor-free Luc-DC-injected C57BL/6 mice highly proliferated in vitro in response to the parental MuTuDC lines devoid of luciferase expression. Here, CD8A is linked to neoplasm.