CD8A and neoplasm: After 4 days of co-culture of splenocytes with DC lines, we observed a CD8+ T cell response that was markedly higher in splenocytes from the C57BL/6, CD4-depleted, and FasL-deficient mice than in splenocytes from the tumor-bearing CD8β-depleted, Pfn-deficient, and CD11c:SV40LgT hosts (Figure 5A,B).