TNF and gastric cancer: Interestingly, NLRP12 and NLRX1, two known NF-κB negative regulators, were markedly down-regulated, while NFKB1 and several NF-κB target genes encoding pro-inflammatory cytokines (IFNB1, IL12A, IL-12B, IL6, and TNF), chemokines (CXCL1, CXCL2, and CCL5) and molecules involved in carcinogenesis (PTGS2 and BIRC3) were markedly up-regulated, in THP-1 cells infected with a highly virulent H. pylori strain isolated from a GC patient.