Studies, conducted in a number of populations, have investigated the association between the polymorphisms NOD1 rs2907749 (246), NOD1 rs7789045 (246), NOD1 rs2075820 (E266K) (179, 247), NOD1 rs5743336 (180), NOD2 rs7205423 (246), NOD2 rs7202124 (164), NOD2 rs2111235 (164), NOD2 rs5743289 (164), NOD2 rs2066842 (P268S) (248, 249), NOD2 rs2066844 (R702W) (250), NOD2 rs2066845 (G908R) (184), and NOD2 rs2066847 (L1007insC) (184, 250), and risk of gastric precancerous lesions and GC (Table 3). The gene discussed is NOD2; the disease is gastric cancer.