Recent studies, conducted in several populations, have shown associations between the polymorphisms TLR1 rs5743618 (Ile602Ser) (154), TLR2 −196 to −174del (155–158), TLR2 rs3804099 (157), TLR4 rs4986790 (Asp299Gly) (155, 157, 159), TLR4 rs4986791 (Thr399Ile) (160), TLR4 rs10116253 (161), TLR4 rs10983755 (162), TLR4 rs11536889 (+3725G/C) (155), TLR4 rs1927911 (161), TLR5 rs5744174 (158), TLR9 rs187084 (−1486 T/C) (163), and CD14 rs2569190 (−260 C/T) (155, 164–167), and risk of GC development in an ethnic-specific manner (Table 1). The gene discussed is TLR4; the disease is gastric cancer.