Given the documented relevance of other NLRs in H. pylori infection and related GC, and that polymorphisms in genes such as NLRP3 (252–255) and CARD8 (255, 256) have been associated with inflammatory gastrointestinal disorders, we addressed, for the first time, the association between 51 polymorphisms in six genes (NLRP3, NLRP12, NLRX1, CASP1, ASC, and CARD8) involved in the NLR signaling pathways and risk of GC in a high risk Chinese population (173). This evidence concerns the gene PYCARD and gastric cancer.