DCLK3 and neoplasm: Furthermore, curcumin was recently shown to polarize myeloid-derived suppressor cells, extracted from a human GC xenograft mouse model, toward a M1-like phenotype with an increased expression of CCR7 and decreased expression of the CLR dectin 1, being both observed in vivo (tumor tissue) and in vitro (splenic myeloid-derived suppressor cells from tumor-bearing mice) (274).