Also, poly(I:C), an agonist of TLR3 and RLRs, has been shown to have a pro-apoptotic effect in vitro, and has significantly inhibited xenograft growth of human GC in a mouse model, through up-regulation of RLRs (RIG-I, MDA-5, and LGP2) as well as an increased expression of Bcl-2 family members, suggesting that it may be a promising chemotherapeutic agent against GC (275). This evidence concerns the gene DHX58 and gastric cancer.