Interestingly, some of these polymorphisms including TLR4 Asp299Gly (159, 184), TLR4 Thr399Ile (184, 185), TLR4 rs10759932 (186), CD14-260 C/T (187), and TLR2 −196 to −174del (157), appear to be involved in the biological continuum that results in intestinal-type GC as they have also been associated with gastric precancerous lesions (Table 2). This evidence concerns the gene TLR4 and gastric cancer.