Given that some authors have failed to show specific associations between polymorphisms in the TLR signaling pathway, especially in TLR2, TLR4, and CD14, and gastric precancerous lesions/GC (157, 160, 162, 164, 172, 174–178, 180–183, 185, 188, 189), we performed the first global meta-analysis to assess the role of TLR2, TLR4, and CD14 polymorphisms in gastric carcinogenesis (155), in an attempt to clarify the limited and current conflicting evidence, and to establish the true impact of the TLR signaling pathway in GC. This evidence concerns the gene TLR2 and gastric cancer.