Strikingly, statistical analyses assessing the joint effect of H. pylori and the selected polymorphisms revealed that H. pylori-infected individuals harboring TLR2 rs3804100, TLR2 −196 to −174del, TLR4 rs11536889, MD-2 rs11465996, MD-2 rs16938755, LBP rs2232578, and TIRAP rs7932766 were at most risk of developing GC (Table 1) (170). The gene discussed is TLR4; the disease is gastric cancer.