In some cancers, such as glioma, prostate cancer, and esophageal adenocarcinoma, high tumor TLR9 expression has been associated with poor survival whereas in others, such as triple-negative breast cancer (TNBC) or renal cell carcinoma, low tumor TLR9 expression upon diagnosis predicts poor prognosis (27, 30, 32, 33, 38, 39). The gene discussed is TLR9; the disease is renal cell carcinoma.