Although all myofibroblasts share common characterizations (such as expression of Col1α1, α-SMA, TGFβRI, TIMP1, PAI-1, activin, vimentin, fibronectin, activation of TGFβ1 signaling pathway), myofibroblasts may originate from distinct cellular sources, and the composition of myofibroblast population may vary dependent on the etiology of liver fibrosis. The gene discussed is ACTA1; the disease is Hepatic fibrosis.