SOD1 and amyotrophic lateral sclerosis: Providing a therapeutic proof-of-principle argument in the role of these metals in ALS are studies in SOD-1 mutant mice where at least three different Fe (Jeong et al., 2009; Wang et al., 2011) and five Cu/Zn-chelating agents have shown significant rescue effects (Hottinger et al., 1997; Nagano et al., 2003; Petri et al., 2007; Tokuda et al., 2008).