In AD, Fe and Cu are thought to play roles in the formation of amyloid-β plaques and tau neurofibrillary tangles (Hane et al., 2013; Savelieff et al., 2013) and recent magnetic resonance image (MRI) studies showed elevated Fe in the hippocampus in AD patients correlating to decreased structural integrity of the hippocampus, possibly caused by a process of demyelination (Raven et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.