SOD1 and amyotrophic lateral sclerosis: Previous studies had shown that SOD-1(G93A) mice with either MT-1/2 or MT-3 knocked-down had accelerated ALS disease course (Nagano et al., 2001) and recently SOD-1G93A mice engineered to also overexpress MT showed significantly enhanced survival together with reduced motor neuron loss and degeneration of ventral root axons and skeletal muscle atrophy.