Considering that disturbances in mitochondrial function are also believed to play a significant role in ALS, it is interesting to note that immunofluorescence staining showed a marked increase in mitochondrial ferritin protein (mitFtn) in the ventral horn motor neurons and astrocytes in 12-month-old SOD-1(G37R) mice but not wild-type mice of the same age mice (Jeong et al., 2009). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.