Although it is controversial, it has been reported that there is a decrease in mTOR signaling in the brains of AD mice (Caccamo et al., 2013; Gouras, 2013; Tang et al., 2013) and AD patients (Lafay-Chebassier et al., 2005; Pei and Hugon, 2008; Sun et al., 2014). This evidence concerns the gene MTOR and Alzheimer disease.