Furthermore, the formation and maturation of synapses in the hippocampus, a mechanism that is impaired in AD (Jacobsenet al, 2006; Smithet al, 2009; Ricobarazaet al, 2012) and depends on IGF2/IGF2R signalling, may underlie the IGF2-dependent memory enhancement effect (Schmeisseret al, 2012). Here, IGF2 is linked to Alzheimer disease.