We analysed IGF2 levels in human AD brain samples (EC and hippocampus), in Tg2576 mice hippocampi and in hippocampal neuronal cultures of Tg2576 mice or hippocampal neuronal cultures of WT mice treated with conditioned medium (CM) containing high concentrations of Aβ peptide, a procedure that induces a reduction in synaptic density similar to that found in AD (DaRocha-Soutoet al, 2012). Here, IGF2 is linked to Alzheimer disease.