Irrespective of various categories such as differences in age (>60), sex, diabetes mellitus, hypertension, and number of comorbidities, the SIRT1 (Table3) and SIRT3 (Table4) levels were still significantly lower in case of frail as compared to nonfrail; however, in case of SIRT2, the differences were not significant (Table5). This evidence concerns the gene SIRT1 and diabetes mellitus.