Although no direct evidence of gross disruption of endosomal vesicles or lysosomes upon interaction with β2m fibrils has been reported, other studies have shown that amyloid sequences can increase the permeability of lysosomal membranes and point to an increase in lysosomal membrane potential as a feature of several amyloid disorders, including Alzheimer’s and Parkinson’s disease [82]–[89]. This evidence concerns the gene B2M and Parkinson disease.