In PD, TLR2 expression was significantly decreased compared to iLBD cases in both the SN and HC (SN Figure 8a-c, a’-c’; Figure 10; iLBD vs PD p = 0.018; iLBD Mean = 5.7 ± 0.9; PD Mean = 3.1 ± 0.5; HC/CA2 Figure 9a-c, a’-c’; Figure 11d; iLBD vs PD p = 0.013; PD Mean = 0.8 ± 0.2). This evidence concerns the gene TLR2 and Parkinson disease.