Activation of the TLR pathway increases the expression of various pro-inflammatory cytokines, like IL-6, IL-1 and TNF-α [36,37].While earlier evidence has been obtained in the field of Alzheimer’s disease (AD) [38,39] and Multiple Sclerosis (MS) [40], recent studies have implicated TLRs also in the pathogenesis of PD [41–44]. This evidence concerns the gene TNF and Alzheimer disease.