RS1 and macular degeneration: The genes over-expressed in male brains include several factors linked to sex in other taxa, such as Tcf12 (involved in estrogen/antiestrogen response in the teleost Fathead minnow [112]), Cbln1 (over-expressed in mouse testis compared to ovaries, as part of the male developmental pathway [113–116]), Rs1 (X-linked gene in human associated to a common macular degeneration in males [117]), Ca12 (involved in the function of uterus in mice [118]), Hyou1 (involved in gonadogenesis in mice [119]) and Aqp1 (possible involvement in the water homeostasis of the male reproductive system [120]).