Therefore, the aim of this study was to simultaneously characterize the expression of Treg (FOXP3 and CTLA4)- and Th17 (RORγt)-related genes in total MM BM samples in order to assess the local immune milieu as potential biomarker/therapeutic target and to understand whether these genes have a prognostic impact on this incurable disease. This evidence concerns the gene CTLA4 and Miyoshi myopathy.