These findings also demonstrate that in the melatonin-suppressed state imposed by LAN, aerobic glycolysis and cAMP-regulated LA uptake and metabolism to 13-HODE operated at a persistently high level throughout the 24-hour day, ostensibly with support from LAN-induced host hyperinsulinemia, hyperglycemia in addition to high IGF-1 blood levels [28]. The gene discussed is IGF1; the disease is hyperinsulinism.