In many tumors, cancer cells take-up LA via a cAMP-dependent transport mechanism and metabolize it to the mitogen 13-hydroxyoctadecadienoic acid (13-HODE) by the enzyme 15-lipoxygenase-1 [9]–[12], the activity of which is up-regulated by activation of epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1) receptors [13], [14]. Here, IGF1 is linked to cancer.