Finally, longitudinal analysis also detected another significant SNP rs439401, which also belongs to gene APOE and is very close to SNP rs4420638; SNP rs4420638 was shown to be related to late on-set Alzheimer's disease [27], [28], dyslipidemia [29], schizophrenia [30], myocardial infarction [31] and psychological stress [32]. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.