The patients with TNFR1 level within the highest tertile were more than 3 times more likely to progress to renal dysfunction than those with cTNFR1 level within the other tertiles (hazard ratio [HR]: 3.39, 95% CI: 1.48–7.78, P = 0.004). This evidence concerns the gene TNFRSF1A and Abnormal renal physiology.