To date, 21 genes associated with KS/nIHH have been identified, namely, KAL1, FGFR1, FGF8, PROKR2, PROK2, CHD7, FGF8, GNRHR, KISS1R, NELF, TAC, TAC3R, GNRH1, KISS1, WDR11, HS6ST1, SEMA3A, SPRY4, IL17RD, DUSP6, FGF17, and FLRT3. Here, FLRT3 is linked to hypogonadotropic hypogonadism.