Further analysis for OS in each subgroup showed that patients with ADAM8 positive tumors have poorer 5-year OS than those with negative ADAM8 in colon cancer (p = 0.006) (Figure 5A), T3/T4 stage (p = 0.023) (Figure 5B) and N0 stage (p = 0.032) (Figure 5C) subgroups compared with rectal cancer, T1/T2 stage and N1-2 stage patients. Here, ADAM8 is linked to rectal cancer.