ADAM8 and neoplasm: The mRNA expression levels of ADAM8 were evaluated by qRT-PCR and representative data are shown in Figures 1B and 1C. The mean expression levels of ADAM8 mRNA were significantly higher in tumor tissues compared with those in adjacent normal tissues (2.74 ± 0.17 vs. 1.04 ± 0.09, respectively; p = 0.0018).