ADAM8 and malignant colon neoplasm: Further analysis for DFS in subgroups showed that patients with positive ADAM8 expression had poorer 5-year DFS than those with negative ADAM8 expression in colon cancer (p = 0.001) (Figure 6A), T3/T4 stage (p = 0.009) (Figure 6B), N0 stage (p = 0.010) (Figure 6C), TNM II stage (p = 0.045) (Figure 6D), adenocarcinoma (p = 0.027) (Figure 6E), moderate differentiation (p = 0.043) (Figure 6F) and male CRC patients (p = 0.030) (Figure 6G) subgroups.