S100A8 and arthritic joint disease: Targeting S100A8/S100A9, we therefore monitored an inflammatory mechanism that has been shown as highly relevant in different mouse models of inflammation like allergies, autoimmune diseases, arthritis and infection and has also proven to be a valuable marker for discrimination and grading of clinically relevant acute and chronic inflammation7, 8, 9, 10, 13, 18, 19.