PAX8 and cancer: Several significantly differentially methylated probes correspond to genes involved in cancer-related mechanisms such as cell death (MCF2L, RASSF5, RASSF6, CASZ1, SLC22A18, IFI27), tumorogenesis (CTSZ, TP73, CTSK, PIK3R1), KLK11, cell cycle (PPM1G, RANBP5, VAMP8) and cell differentiation (SMAF1, PAX6, PAX8).