Several significantly differentially methylated probes correspond to genes involved in cancer-related mechanisms such as cell death (MCF2L, RASSF5, RASSF6, CASZ1, SLC22A18, IFI27), tumorogenesis (CTSZ, TP73, CTSK, PIK3R1), KLK11, cell cycle (PPM1G, RANBP5, VAMP8) and cell differentiation (SMAF1, PAX6, PAX8). The gene discussed is PIK3R1; the disease is cancer.