So far, validated targets of mir-21 included programmed cell death 4 gene (PDCD4), tropomyosin 1 (TPM1), phosphatase and tensin homolog (PTEN), chromosome condensation protein G (NCAPG), reticulon 4 isoform A (RTN4) and other cancer-related genes [12]–[15], [17], [44]–[46]. This evidence concerns the gene RTN4 and cancer.