Finally, the peak signal corresponding to Fibrinogen (Fbg) was found significantly upregulated in PrMS compared to CIS (p = 0.005) and RRMS (p = 0.047) subjects, and the intensity of the signal related to Fibrinopeptide A (FPA) was significantly higher in PrMS compared to CIS subjects (p = 0.040) (Table 3). This evidence concerns the gene FGA and in situ carcinoma.