The standard biomarkers that significantly predict the clinical and biochemical recurrence of prostate cancer are preoperative serum prostate-specific antigen (PSA), pathological grade according to Gleason score, positive surgical margins (with and without extraprostatic extension), and capsular incision adding up the following factors as of prognostic significance: presence of perineural, angiolymphatic, seminal vesicle invasion and extraprostatic tissue invasion. Here, KLK3 is linked to Familial prostate cancer.