LDHA and neoplasm: Any method of lactate downregulation such as MCT1,4 or LDH-A inhibition therapies can be designed for the tumour state similar to the case in figure 6c, where the cancer cell population can alter from a high lactate uptake state to a high glucose respiration state, thus the therapeutic outcome would be a sudden decrease in tumour cancer cell metabolic coupling which can lead to decreased tumorigenesis.