Aspirin-exacerbated respiratory disease (AERD) is a difficult-to-treat chronic inflammatory disease characterised by asthma, chronic rhinosinusitis with nasal polyposis and sensitivity to aspirin and other cyclo-oxygenase 1 (COX-1) inhibiting non-steroidal anti-inflammatory drugs (NSAIDs) [1]. The gene discussed is PTGS1; the disease is chronic rhinosinusitis.