Although multiple studies have shown that the genetic predisposition to VKH disease is contributed by multiple overlapping factors encoded by the HLA system, the strengths of association between HLA-DRB1*04 subtypes and VKH disease vary among different races, indicating that the pathogenesis of VKH may be multifactorial with additional genetic susceptibility and environmental causes [[32],[34]]. This evidence concerns the gene HLA-DRB1 and Vogt-Koyanagi-Harada disease.