Besides, an animal model of renal failure- (RF-) induced hypertension study showed that the antihypertensive mechanism of EA may be related to the effects of oxidative stress on insulin-like growth factor-I (IGF-I), inducible nitric oxide synthase, heme oxygenase, and thiobarbituric acid-reactive substance expression [73]. Here, IGF1 is linked to Renal insufficiency.