AURKA and cancer: The AURKA gene is often amplified in many malignancies, and its overexpression has been reported to be significantly associated with a higher tumor grade and a poor prognosis in a number of cancers, such as chondrosarcoma, nasopharyngeal carcinoma, ER-positive breast cancer, glioblastoma, colorectal cancer, gastric cancer, and endometrioid ovarian carcinoma [54–60].