The results showed that individuals with ABCB1 TT genotype and T allele were associated with high risk of death from osteosarcoma when compared with wide-type genotype, with HRs(95%CI) of 2.58(1.03-7.28) and 1.65(1.03-2.72), respectively. The gene discussed is ABCB1; the disease is osteosarcoma.