PCR amplifications of the hemochromatosis gene and apo E genes were obtained using freshly drawn untreated blood samples tested by PCR.14 Genetic diagnostic tests will assist in the identification of FH while improving cardiovascular risk prediction, prevention of disease and treatment efficacy.15,16 About 35% classical and 65% probable cases of heterozygous FH were observed with mutation at exon 3 and 4 in Pakistani population.17 Here, APOE is linked to hemochromatosis.