TP53 and neoplasm: In the specimens of 45 invasive ductal carcinoma, the expression rate of HPV16/18 DNA and p53 protein in patients with axillary lymph node metastasis is significantly higher than those without (p<0.05); The expression rate of p53 protein increase with TMN staging advancing (p<0.05), while neither of the expression rates of HPV16/18 DNA and p53 protein is significantly correlated with age or tumor size (p>0.05) (Table-II).