Being natural sources of growth factors like insulin-like growth factor 1 (IGF-1), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), or transforming growth factor β (TGF-β) caused the platelets to have important role in different processes such as inflammation, angiogenesis, repair and regeneration of the tissues.10 In TPL patients, due to inflammation and possible ongoing ischemia process, we hypothesized that platelet activation indices like MPV and PDW should be altered than the controls. This evidence concerns the gene IGF1 and ischemia.