CHGA and irritable bowel syndrome: A previous study performed by our group found that a change in food intake in IBS patients established by dietary guidance reduced the symptoms and improved the quality of life in these patients.5 Investigation of the total gastric endocrine cell population, as revealed by chromogranin A staining, revealed that in the same patient cohort the density of gastric endocrine cells tended to normalize following dietary guidance.6 The aim of the present study was to identify which gastric endocrine cell types were affected by a change in food intake in that same cohort of IBS patients.5,6