Our previous study shows that IKK-β activation phosphorylates the serine-644 residue in the FOXO3 protein and subsequently triggers faster protein degradation of FOXO3 via the proteasome-mediated ubiquitination (Ub) mechanism, which results in the stimulation of human breast cancer cell proliferation in vitro and the development of breast tumor in vivo (11,12). The gene discussed is FOXO3; the disease is breast neoplasm.