FTO and obesity due to melanocortin 4 receptor deficiency: The minor (risk) allele frequency of rs8050136, located in the first intron of the fat mass and obesity associated (FTO) gene, by subgroup is illustrated in Additional file 1: Figure S9; a relative enrichment of risk alleles in the PRISm – Metabolic subgroup was noted among African American subjects (ANOVA p-value 0.05), however, this enrichment was not statistically significant among non-Hispanic white subjects.