Mechanisms underlying the progression of late-onset AD consist of a number of interacting events including excessive accumulation of amyloid, aberrant tau-protein phosphorylation, oxidative stress, chronic inflammatory conditions, excitotoxicity, disruption of neurotrophine signaling, impairments in cytoskeleton stability and axonal transport, synaptic and neuronal loss [2]. This evidence concerns the gene MAPT and Alzheimer disease.