As shown in Fig. 3C, SST0116CL1 induced a relevant decrease of the protein levels of three typical client proteins (c-MET, AKT and CDK4) in GTL-16 tumor lysates and, at the same time, significantly increased the expression levels of the chaperone Hsp70, thus confirming that inhibition of Hsp90 function was achieved. This evidence concerns the gene AKT1 and neoplasm.