HSP90AA1 and neoplasm: As shown in Fig. 3C, SST0116CL1 induced a relevant decrease of the protein levels of three typical client proteins (c-MET, AKT and CDK4) in GTL-16 tumor lysates and, at the same time, significantly increased the expression levels of the chaperone Hsp70, thus confirming that inhibition of Hsp90 function was achieved.