Lin and colleagues observed a significant decrease in IL-6 levels after metformin treatment in PCOS women (IL-6 level decreased from 28.05 ± 3.26 to 22.04 ± 2.76 pg⁄mL after metformin treatment in PCOS women, p = 0.0342) [6]. Here, IL6 is linked to polycystic ovary syndrome.