By using TargetScan 5.1 and PicTar, we predicted putative genes of miR-194, and obtained several putative targets correlating with tumor growth or metastasis, such as QKI, KIAA1239, EPHA5, NACC2, MCTS1 and SAMD4A. In general, the discovery of miRNA and their functions, has introduced a new dimension to our existing knowledge of signaling molecules and pathways for more precise therapeutic targeting. This evidence concerns the gene SAMD4A and neoplasm.