SH3BP2 and cherubism: In 1999, however, a distinct genetic basis for cherubism was established, thereby cleaving it from its erroneous title of “fibrous dysplasia of the jaw.” Following the mapping of cherubism to chromosome 4p16.3 [10]–[14], Ueki et al. [13] traced the development of the disorder to a series of point mutations causing amino acid substitutions in the SH-3 binding protein SH3BP2 [12].