SOD1 and amyotrophic lateral sclerosis: Fuchs and colleagues [40], using visually guided patch-clamp recordings in combination with single cell Ca2+ imaging of motor neurons throughout the complete lifespan of the SOD1(G93A) ALS mouse, reported that the pre-symptomatic motor terminals (70 days ∼7 weeks) present hyperexcitability in association with remodeling of Ca2+ handling.