SOD1 and amyotrophic lateral sclerosis: Given the unexplored role of A2A receptors at the neuromuscular junction in ALS, and considering that the neuromuscular transmission in the SOD1(G93A) mice starts to present alterations long before symptoms onset [7], we considered of interest to evaluate A2A receptor effects on neuromuscular transmission, in both pre-symptomatic (4–6 weeks old) and symptomatic (12–14 weeks old) SOD1(G93A) ALS mice.