In SW620 colorectal cancer cells which express endogenous mutant KRAS, Ponatinib and AMG-47a were highly toxic at concentrations required to observe loss of EGFP-KRASG12V in HeLa cells (>1 μM), thus we were unable to test whether these compounds also affect the levels of endogenous KRAS oncoprotein. The gene discussed is KRAS; the disease is colorectal cancer.