We could thus validate the specific requirement of 10 genes out of the 150 candidate genes tested for lifespan extension and pathogen resistance, including the PTEN tumor repressor daf-18, proteasomal complex genes (rpn-6.1, rpn-7, rpn-9, rpn-10, rpt-6, pbs-3 and pbs-6) and two novel genes (par-5 and T12G3.6). This evidence concerns the gene PSMD6 and neoplasm.