In the present study, we identified the distinct features of five macroscopic phenotypes of conventional neoplasms based on genetic alterations and DNA methylation profiles as follows: PN, high frequency of KRAS mutation; LST-G, high frequency of CIMP, KRAS and PIK3CA mutation and LINE-1 hypomethylation; LST-NG, relatively high frequency of TP53 mutation; DN, high frequency of TP53 mutation and LINE-1 hypomethylation; S-FN, rare methylation changes and genetic alterations. The gene discussed is TP53; the disease is neoplasm.