Ewing sarcoma is a prototypical chromosomal translocation-associated malignancy, in which virtually all cases harbor a balanced somatic translocation fusing the EWSR1 gene (EWS) to a member of the (E- twenty six) ETS-family of transcription factors, most commonly FLI1 (FLI) [1], [2]. The gene discussed is FLII; the disease is Ewing sarcoma.