BRCA1 and cancer: The objective of this score was to provide a comprehensive means of assessing defects in HR beyond sequencing of BRCA1 and BRCA2. To evaluate the correlation between HRD score and HR deficiency, three independent HGSC cohorts along with 57 cancer cell lines were assessed for bi-allelic functional inactivation of BRCA1, BRCA2, or RAD51C through the integration of mutation, methylation, expression, and LOH data.