Furthermore, in the phase II PrECOG 0105 study of gemcitabine and carboplatin plus iniparib (BSI-201) as neoadjuvant therapy for TNBC and BRCA1/2 mutation-associated breast cancer, 70% of patients with an HRD score of more than 9 responded compared with 20% of patients with an HRD score of less than 10, indicating that HRD score was significantly correlated with pathologic response. This evidence concerns the gene BRCA1 and breast cancer.