Notably, several genes such as ALX4 [44], CHD5 [45], MYOD1 [46], NEUROG1 [47], and RASSF5 [48], whose methylation profile distinguishes this group of HCC patients from the other HCC patients, were previously reported to be similarly hypermethylated and associated with poor prognosis in colorectal cancer (Table S3). Here, RASSF5 is linked to hepatocellular carcinoma.